![]() The infection of pregnant macaques with this virus results in maternal viremia, virus crossing into the amniotic fluid (AF), and in utero fetal deaths. Here, we infect pregnant rhesus macaques ( Macaca mulatta) with a minimally passaged ZIKV isolate from Rio de Janeiro, where a high rate of fetal development complications was observed. Zika virus (ZIKV) infection of pregnant women is associated with pathologic complications of fetal development. Setup automated workflows to increase efficiency, control processes, and reduce human error in your research. Import and export most industry standard file formats. Track history and parent descendant lineage throughout cloning processes.īatch BLAST against NCBI and directly search GenBank. Find restriction sites digest, ligate, and perform Golden Gate, Gibson, and Gateway cloning.ĭesign primers, find CRISPR sites, and optimize codons. View plasmid maps, automatically annotate vectors, and copy-paste sequences with annotations. View and edit alignments with real-time translation and highlighting.īuild phylogenetic trees using peer-reviewed algorithms, including RAxML and PAUP*. Perform pairwise and multiple alignments using trusted algorithms, including MAFFT and ClustalW. ![]() Genotype microsatellite traces with automated ladder fitting and peak calling and generate tables of alleles. Automatic annotation for gene prediction, motifs, translation, and variant calling. Trim, assemble, and view Sanger sequencing trace files.
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